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GI Nurse Reveals the “Upstream Blockage” That’s Paralyzing 73% of Ozempic Patients (And Why Miralax Can’t Reach It)

“I’ve been a GI nurse for 22 years. I should have questioned why my patients kept suffering despite taking everything their doctors recommended. Now I’m furious at how many are stuck in the laxative trap.” — Karen Mitchell, RN

Gut Health Insider | January 2026 | 7 min read
Doctor explaining GLP-1 side effects to patient

Lisa Hartman should be planning her vacation right now. She’s back in bed with her husband instead.

If you’ve ever taken Miralax for a week straight and still felt like you swallowed a bag of cement…

If you’ve had sulfur burps so foul your husband moved to the guest room…

If you’ve cycled between “nothing works” and “everything comes out at once” for months…

If you’ve spent hundreds on laxatives that betray you three days later…

Then what a GI nurse discovered after watching her patients suffer for two years could change everything.

There’s a hidden problem affecting 73% of GLP-1 patients right now.

It’s causing them to cycle through every laxative at CVS while the real problem gets worse.

And here’s what makes GI nurses furious: The very treatments you’ve been told to use can’t reach where the problem actually lives.

I’m not talking about constipation in the normal sense.

I’m talking about what happens when your stomach stops moving—and everything you try only works on the exit while the entrance stays blocked.

A Nurse Who Refused to Watch Her Patients Suffer

Karen Mitchell had spent 22 years as a GI nurse in Philadelphia. Thousands of patients.

But in the past two years, she started seeing something different.

Women who’d lost 30, 40, 50 pounds on these medications. Women whose doctors called them success stories. Women who were suffering in ways they’d never tell their physicians.

They’d take Miralax. Nothing. Add Dulcolax. Still nothing. Drink a whole bottle of magnesium citrate over a weekend.

Then either nothing happened—or everything happened at once. And within a week, they were right back to being stuck.

“That’s just how these medications work,” her colleagues told her.

Karen accepted that. Until Lisa Hartman.

Lisa was 58. Four months on Mounjaro. Down 47 pounds.

And she was seriously considering quitting.

“I haven’t gone in eleven days,” Lisa said, tears in her eyes. “I drank an entire bottle of Miralax over a weekend. Nothing. I’ve tried everything.”

She paused.

“And the burps. They smell like something died inside me. My husband sleeps in the guest room now.”

Three weeks later—Lisa was worse.

“I finally went after taking enough magnesium citrate to kill a horse. Was afraid to leave my bathroom for two days. Then three days later? Right back to being stuck.”

Her voice cracked.

“I’ve lost 47 pounds. My doctor says I’m a success story. But I’m miserable.”

Karen didn’t have an answer.

What One Conversation Revealed at 11 PM

That night, Karen called a friend in gastroenterology research.

“Karen, you’re treating the wrong end of the problem.”

“What do you mean?”

“Miralax works on the colon. The exit. But GLP-1 medications don’t cause problems in the colon. They cause problems in the stomach.”

Karen stopped.

“These drugs slow gastric emptying. That’s the point. But in a lot of patients, the stomach doesn’t just slow down. It practically stops. Food sits there for 12, 18, sometimes 24 hours.”

“So the laxatives…”

“Can’t reach where the problem is. You’re trying to unclog a drain when the water is shut off at the source.”

Karen thought about every patient she’d seen. The ones taking Miralax daily with no results. The ones cycling between “nothing works” and “everything at once.”

They’d all been treating their colons.

While their stomachs stayed paralyzed.

Your Miralax Can’t Reach What’s Actually Blocking You

Stomach diagram showing food fermentation

Karen called Lisa the next morning.

“When you take Miralax, it works on your colon. The exit. But the medication you’re on is affecting your stomach. The entrance.”

Lisa stared.

“Your stomach isn’t emptying. Food sits there for a day or more. That’s why you feel like you swallowed cement. That’s why the burps smell like rotten eggs—your food is literally fermenting inside you.”

“But I’m taking Miralax every day—”

“And it’s working exactly as designed. On your colon. But your colon isn’t the problem.”

“So everything I’ve been doing…”

“Has been treating the exit while the entrance stays blocked.”

“Why didn’t anyone tell me this?”

“Because most people don’t think to look for it. They see constipation and prescribe laxatives. They don’t realize the constipation is just the end result of a stomach that stopped moving.”

Mechanism explanation diagram

What GI Nurses Have Quietly Recommended

Karen reached out to colleagues. Asked what worked when laxatives kept failing.

One nurse told her about a patient stuck for two weeks. “She started using some celery gummy thing. Within a week, she was going regularly. No cramping. No disasters.”

Another nurse had recommended it to her own mother. “She was cycling through Miralax for months. Started these gummies. The sulfur burps stopped in four days. She’s been regular for two months.”

The same formula every time: Celery juice compounds for motility. Chlorophyll for the gas. A gentle prebiotic for downstream hydration.

Karen found one company making exactly this combination: Motilli.

Not a laxative. Something that actually addressed the upstream problem.

Motilli product image

“I can’t officially recommend this,” Karen told Lisa. “But if I were dealing with what you’re dealing with, I’d want to know it exists.”

She explained:

1

Wake up the stomach muscles.

Compounds in celery help wake up your stomach muscles. Natural prokinetics. They nudge the muscles to start moving again.

2

Neutralize the sulfur burps.

Chlorophyll neutralizes the hydrogen sulfide causing the sulfur burps. Internal deodorant.

3

Soften what’s downstream.

A gentle prebiotic that dissolves and draws moisture into whatever reaches your colon. Softens things so they actually move.

Lisa looked skeptical. “A gummy?”

“Miralax was never designed to fix this. It works downstream. Your problem is upstream. This actually addresses where the blockage is.”

The bottle arrived three days later.

Lisa left it on her counter.

Celery juice gummies. Really.

She thought about the $400 she’d wasted on supplements. The Miralax that did nothing. The Dulcolax that worked once and never again.

Why would this be different?

But she kept thinking about what Karen said. Treating the exit when the entrance was blocked.

On the fourth day, she tried them.

Three gummies. Tasted like green apple. Nothing dramatic.

Week One: Something Shifts

Patient results and reports
Day 2

Day 2

The heavy, brick-like feeling in her stomach—the one she’d felt every day for four months—was lighter. Not gone. But lighter.

Day 4

Day 4

She realized she hadn’t had a sulfur burp since Tuesday.

Day 6

Day 6

She went to the bathroom. Not violently. Not explosively. Just normally.

Wk 3

Week 3

She’d gone five times that week. Regular. Predictable. No emergencies.

Mo 2

Month 2

Lisa texted Karen a photo. Her and her husband at a restaurant. “First time I’ve eaten out without planning an escape route in six months.”

She threw out the Miralax.

Why Your Doctor Will Never Tell You This

Karen tried to share what she’d learned. Most colleagues shrugged.

“Laxatives are standard of care. We can’t recommend supplements.”

GLP-1 medications generate billions annually. Laxatives generate billions more.

A patient who addresses the upstream problem doesn’t need to cycle through Miralax every week.

But word spread anyway. Support groups shared it. Nurses mentioned it quietly.

Motilli couldn’t get FDA approval for medical claims—trials cost hundreds of millions.

So they market it as a “digestive support supplement.” Same formula. Available without prescription.

Your Constipation Isn’t Permanent—Your Stomach Just Needs to Wake Up

You have two choices.

Keep taking laxatives that only work downstream. Keep cycling between “nothing works” and “everything at once.”

Or try what GI nurses have been quietly recommending. What actually addresses where the problem lives.

Lisa chose to try it. Her husband’s back in their bedroom.

Every day you wait, your stomach stays asleep.

Check Availability

✓ 60-Day Money-Back Guarantee

Try Motilli for 60 days. If you don’t:

✓ Feel the “brick” in your stomach start to lift within the first week

✓ Notice the sulfur burps fading or disappearing

✓ Start going regularly without cramping or “disaster days”

…send it back for a full refund. No questions.

87% of people who try Motilli order more within 60 days.

&x26A0; Limited Supply: Due to high demand from GLP-1 support groups, current inventory is 68% sold out. Orders ship within 24 hours while stock lasts.

Don’t Believe Us? Here’s What Others Are Saying:

“I drank an entire bottle of Miralax over a weekend and nothing happened. My daughter found this article. Started the gummies on a Monday. By Thursday the sulfur burps were gone. By the following week I was going regularly for the first time in three months. My husband asked what was different. I just smiled. He’s back in our bedroom now.”

— Sandra T., 61, Verified Buyer

“Four months on Wegovy. Tried Miralax, Dulcolax, Mag07, everything. Nothing worked or it worked once then stopped. Was seriously thinking about quitting. Started Motilli after reading about the upstream/downstream thing. First week the brick feeling lifted. Second week I went to the bathroom three times without any laxatives. It’s been two months. I threw out everything else in my medicine cabinet.”

— Deborah M., 54, Verified Buyer

“Honestly I was skeptical. I’d wasted so much money on stuff that didn’t work. But I was desperate. The sulfur burps were ruining my life—I was afraid to open my mouth in meetings. Started these gummies. Four days later the burps stopped. Just stopped. I actually cried. It’s been six weeks and they haven’t come back. I don’t know why this works when nothing else did but I don’t care. I’m ordering three more bottles.”

— Janet L., 58, Verified Buyer

Check Availability

✓ 60-Day Money-Back Guarantee

Hurry—current batch is 68% sold out.

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Motilli is a dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease. Consult your doctor before starting any new supplement, especially if you are on GLP-1 medications.